Endocrine Abstracts

Folate and cobalamin are methyl donors (MD) needed for synthesis of methionine, precursor of S-adenosylmethionine (SAM), the substrate of methylation in epigenetic, and epigenomic pathways. The MD deficiency (MDD) leads to a decrease in SAM/SAH ratio and hyperhomocysteinemia, which has been related to osteoporosis in humans and disruption of development of epiphyseal cartilage in rat. However, the underlying molecular mechanisms remain elusive.M...

Patients with hypopituitarism and untreated growth hormone (GH) deficiency have excess mortality. GH replacement therapy (GHRT) has many beneficial effects, but its impact on mortality has not been proven and there are still safety concerns regarding the potential cancer risk. We have therefore studied the mortality in non-functioning pituitary adenoma (NFPA) patients with and without GHRT. Only patients with NFPA were studied in order to eliminate the influence of the aetiolo...

Introduction: HIV infection and combined antiretroviral therapy (cART) have been associated with lipodistrophy and changes in body composition. However, there are few studies on body composition evolution of HIV-infected patients, under cART.Aims: To evaluate the evolution of body composition in HIV-1 infected patients under cART over 5 years.Methods: Retrospective, observational study in a cohort of HIV-infected patients on cART. ...

Background: Survivors of childhood leukaemia (ALL) treated with cranial radiotherapy (CRT) are at risk for cognitive impairment. Whether the impairment progresses with follow-up time and if survivors with cognitive impairment have an increased risk for overweight, is unknown. We aimed to investigate the long-term cognitive functioning in ALL survivors treated with CRT in comparison to matched controls.Method: Cognitive functioning was investigated in 38 ...

Introduction: Pituitary surgery is currently considered the preferred treatment for Cushing’s disease (CD) and achieves remission in 55–85% of patients. Cortisol falls quickly after surgery, so that early post-operative cortisol level has been used as predictor of remission. There’s no agreement about optimal timing for cortisol measurement, with wide variability between centres.Objective: To assess the value of early post-operative serum ...

Introduction: Cushing’s disease (CD) is characterised by pathologic hypercortisolism caused by an ACTH-secreting pituitary adenoma. The primary modality for definitive treatment is pituitary surgery. The rarity of CD has made it difficult to establish reliable predictive factors of outcomes.Aim: Assessment of clinical, hormonal, radiological, surgical and histological findings as predictors of remission and relapse of CD.Metho...

Objective: Our aim was to evaluate whether multiple mild head trauma or repetitive heading of long term soccer playing causes growth hormone deficiency.Patients and methods: 28 retired previously professional male soccer players were investigated. Nine of them had sport related head injuries. Mean age: 48.7 years (range 36–70; S.D.±7.4); mean sport duration (professional and senior activity): 27.4 years (S.D.±...

Thyroid cancers represent ~1% of new cancer diagnoses. Thyroid malignancies are divided into papillary carcinomas (80%), follicular carcinomas (10%), medullary carcinomas (5–10%), anaplastic carcinomas (1–2%), and other rare tumours (primary thyroid lymphomas and primary thyroid sarcomas). The main therapeutic options are surgery (mainly total thyreoidectomy), radioiodine treatment, levothyroxine therapy (TSH suppression dose), others (external beam irradiation, chem...

In the present study, we investigated neural alterations in newly diagnosed patients with mild hypothyroidism due to Hashimoto’s thyroiditis alongside mood and cognition as well as changes with treatment initiation. Animal studies and first studies of human brain metabolism using radioactive tracers suggest neural involvement in affective and cognitive symptoms of hypothyroidism. Here, we introduce non-invasive magnetic resonance imaging (MRI) techniques that allow the an...

Introduction: Congenital adrenal hyperplasia (CAH) is a prevalent disturb in female to male gender identity disorder (GID). However, psychoendocrinology of GID is not yet fully understood.Case Report: A 22-year-old patient(46, XX), was sent from Psychiatry-Sexology to Endocrinology consultation for GID to start hormonal treatment. Self-awareness as a male began at 12-year-old. Menarche at the age of 13 years. At 14-year-old, it was noticed overgrowth of ...